The paper offers a critical interrogation of the politics of hope in relation to suffering in the world. It begins with a critique of the assumptions and aspirations of ‘philosophies of hope’ that assume a Levinasian responsibility for the suffering-Other. Such approaches to thinking hope reveal an underlying coloniality of ontology, of totality/exteriority, which defines Being and Non-Being, presence and absence, in totality. Consistent with past colonial rationalities, the logics of salvation and rescue define, still, these contemporary envisioning of the ‘white man’s burden’ in relation to the suffering Other. A decolonial ontology of Exteriority, of an incommensurable radical Other-Being against Totality, is instead presented. The focus here shifts from the passive suffering-Other that is the object of rescue, to the Radical Other that is the author of encounter. By returning Exteriority (the Radical Other-in-the-World) to theory, and by opening up theory’s locations of enunciation, the implications of responsibility, in thinking hope, become open also to interrogation and vulnerable to unsatisfactory conclusions.